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[Immunologic analysis of the antigenic properties of neuraminidase from drift-variants of influenza virus B].

Authors
  • Rovnova, Z I
  • Rogacheva, T A
  • Platonova, A L
  • Isaeva, E I
Type
Published Article
Journal
Voprosy virusologii
Publication Date
Jan 01, 1988
Volume
33
Issue
6
Pages
669–674
Identifiers
PMID: 3073569
Source
Medline
License
Unknown

Abstract

The antigenic features of neuraminidases of several drift variants of influenza B virus were studied by enzyme immunoassay using antiserum to influenza B/USSR/100/83 virus neuraminidase isolated by pronase. Studies using immunosorption and competitive solid-phase enzyme immunoassay showed the presence in the antineuraminidase serum of at least two antibody subpopulations capable to inhibiting the activity of the enzyme and interacting with neuraminidase antigenic determinants: one detecting the antigenic determinant common for B/100/83 and B/Lee/40 viruses, and the other characterizing the antigenic determinant inherent in neuraminidase of B/100/83 virus and enzymes of drift variants isolated in 1970-1986 and lacking in the enzyme of B/Lee/40 virus.

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