Hepatitis B virus antigen screening in the liver of organ and tissue donors was performed. The results of a 4-year period are compared with the serological findings. The immunohistochemical and serological data altered in two out of 15 organ donors. HBV antigen could be detected in the liver, however the serological examination was negative in these persons. The author emphasize the risk of a possible hepatitis B virus transmission through organ and tissue transplantation. A detailed examination of the donors is suggested.