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Immunohistochemical staining of endomorphin 1 and 2 in the immune cells of the spleen.

Authors
Type
Published Article
Journal
Peptides
0196-9781
Publisher
Elsevier
Publication Date
Volume
25
Issue
1
Pages
91–94
Identifiers
PMID: 15003360
Source
Medline
License
Unknown

Abstract

Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for EMs in this area. The current study examines the localization of EM-1 and -2 in the immune cells of the spleen of male and female rats via an immunohistochemical procedure. In both genders, EM-1 and -2 immunoreactive staining was predominantly present in macrophages and B cells with minimal EM immunoreactive staining in T cells. This is the first evidence of a differential distribution of EM-1 and -2 in cells of the immune system.

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