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Immunohistochemical localization of Notch signaling molecules in ameloblastomas.

Authors
  • Muraki, E1
  • Nakano, K
  • Maeda, H
  • Takayama, M
  • Jinno, M
  • Kubo, K
  • Yoshida, W
  • Hasegawa, H
  • Kawakami, Toshiyuki
  • 1 Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan. , (Japan)
Type
Published Article
Journal
European journal of medical research
Publication Date
Jun 21, 2011
Volume
16
Issue
6
Pages
253–257
Identifiers
PMID: 21810559
Source
Medline
License
Unknown

Abstract

We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequently positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.

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