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Immunohistochemical detection of paralogous 13 HOX genes in phyllodes tumor of the breast as a useful diagnostic tool

Authors
  • Sarno, Sabrina1
  • Cerrone, Margherita2
  • Gigantino, Vincenzo2
  • Scognamiglio, Giosuè2
  • Cantile, Monica2
  • Botti, Gerardo3
  • Di Bonito, Maurizio2
  • 1 Università degli Studi di Napoli Federico II, Naples, Italy
  • 2 Pathology Unit, Istituto Nazionale Tumori-Irccs-Fondazione G. Pascale, Naples, Italy
  • 3 Scientific Direction, Istituto Nazionale Tumori-Irccs-Fondazione G. Pascale, Naples, Italy
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Sep 01, 2020
Volume
13
Issue
9
Pages
2348–2351
Identifiers
PMID: 33042341
PMCID: PMC7539888
Source
PubMed Central
Keywords
License
Unknown

Abstract

Phyllodes tumor of the breast is a rare fibroepithelial lesion characterized by a propensity for local recurrence and distant metastasis. Its histologic classification, based on morphology, mitotic index and tumor margin, includes malignant, borderline, and benign. These tumors show similar cellular morphology, which may contribute to difficulty in classifying them histologically and in prediction of their clinical behavior. Thus, the identification of new biomarkers detectable also by in situ methods has become indispensable. Paralogous HOX13 genes (HOX A13, HOX B13, HOX C13 and HOX D13) play a relevant role in tumor development and progression in particular in breast cancer. In this study we analyzed the immunohistochemical expression of paralogous HOX13 homeoproteins on a phyllodes tumor case series to validate their usefulness in histologic classification.

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