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Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases.

Authors
  • Hadzidimitriou, Anastasia
  • Stamatopoulos, Kostas
  • Belessi, Chrysoula
  • Lalayianni, Chrysavgi
  • Stavroyianni, Niki
  • Smilevska, Tatjana
  • Hatzi, Katerina
  • Laoutaris, Nikolaos
  • Anagnostopoulos, Achilles
  • Kollia, Panagoula
  • Fassas, Athanasios
Type
Published Article
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Publication Date
Jun 01, 2006
Volume
91
Issue
6
Pages
781–787
Identifiers
PMID: 16769580
Source
Medline
License
Unknown

Abstract

Biases in IG repertoire did not seem disease-related but followed a similar pattern to that of the normal repertoire. The under-representation of the IGHV4-34 gene provides an explanation for the paucity of autoimmune phenomena in MM. Somatic mutation patterns indicate the complementary role of MM IGH/IGK/IGL sequences in antigen recognition. Finally, the frequent inactivation of productive IGKV-J joints by secondary rearrangements in MM suggests active receptor editing.

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