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Immunoglobulin deficiencies and meningococcal disease.

Authors
  • Castagliuolo, P P
  • Nisini, R
  • Quinti, I
  • Fattorossi, A
  • D'Amelio, R
Type
Published Article
Journal
Annals of allergy
Publication Date
Jul 01, 1986
Volume
57
Issue
1
Pages
68–70
Identifiers
PMID: 3729084
Source
Medline
License
Unknown

Abstract

Five male military recruits were studied for evidence of immunologic deficiencies. Four had recovered recently from a first-episode meningococcal meningitis and one presented with recurrent meningococcemia. A selective decrease in IgG and IgA was found in one of the first-episode patients and a selective IgG2 subclass deficiency in the recurrent case. No complement abnormalities were detected, however, in any of the five cases. These results present further proof of the crucial role of immunoglobulins in the defense against N. meningitidis and they stress the necessity of a through examination of humoral immunity before military career enlistment.

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