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Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants.

Authors
  • Kaplan, S L
  • Lauer, B A
  • Ward, M A
  • Wiedermann, B L
  • Boyer, K M
  • Dukes, C M
  • Schaffer, D M
  • Paisley, J
  • Mendelson, R
  • Pedreira, F
Type
Published Article
Journal
The Journal of Pediatrics
Publisher
Elsevier
Publication Date
Feb 01, 1994
Volume
124
Issue
2
Pages
323–327
Identifiers
PMID: 8301447
Source
Medline
License
Unknown

Abstract

Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 micrograms/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants.

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