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Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation.

Authors
  • Kono, K1
  • Mimura, K
  • Kiessling, R
  • 1 Department of Surgery, National University of Singapore, Singapore. [email protected]
Type
Published Article
Journal
Cell Death and Disease
Publisher
Springer Nature
Publication Date
Jun 20, 2013
Volume
4
Identifiers
DOI: 10.1038/cddis.2013.207
PMID: 23788045
Source
Medline
License
Unknown

Abstract

Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. In this review, we will discuss and summarize molecular and cellular mechanisms underlying immunogenic tumor cell death induced by chemoradiotherapy, with emphasis on a clinical translation.

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