Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation.
- Authors
- Type
- Published Article
- Journal
- Cell Death and Disease
- Publisher
- Springer Nature
- Publication Date
- Jun 20, 2013
- Volume
- 4
- Identifiers
- DOI: 10.1038/cddis.2013.207
- PMID: 23788045
- Source
- Medline
- License
- Unknown
Abstract
Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. In this review, we will discuss and summarize molecular and cellular mechanisms underlying immunogenic tumor cell death induced by chemoradiotherapy, with emphasis on a clinical translation.