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Immunogenic properties of immunoglobulin superfamily members within complex biological networks.

Authors
  • Odales, Josué1
  • Guzman Valle, Jesus1
  • Martínez-Cortés, Fernando1
  • Manoutcharian, Karen2
  • 1 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), AP 70228, Ciudad Universitaria, México, DF 04510, Mexico. , (Mexico)
  • 2 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), AP 70228, Ciudad Universitaria, México, DF 04510, Mexico. Electronic address: [email protected] , (Mexico)
Type
Published Article
Journal
Cellular Immunology
Publisher
Elsevier
Publication Date
Dec 01, 2020
Volume
358
Pages
104235–104235
Identifiers
DOI: 10.1016/j.cellimm.2020.104235
PMID: 33137645
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Antibodies, T cell receptors and major histocompatibility complex molecules are members of the immunoglobulin superfamily and have pivotal roles in the immune system. The fine interrelation between them regulates several immune functions. Here, we describe lesser-known functions ascribed to these molecules in generating and maintaining immune response. Particularly, we outline the contribution of antibody- and T cell receptor-derived complementarity-determining region neoantigens, antigenized antibodies, as well as major histocompatibility complex class I molecules-derived epitopes to the induction of protective/therapeutic immune responses against pathogens and cancer. We discuss findings of our own and other studies describing protective mechanisms, based on immunogenic properties of immunoglobulin superfamily members, and evaluate the perspectives of application of this class of immunogens in molecular vaccines design. Copyright © 2020 Elsevier Inc. All rights reserved.

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