[Immunodiagnosis of immune thrombocytopenias and their clinical significance].
- Published Article
Allergie und Immunologie
- Publication Date
Jan 01, 1990
Immune thrombocytopenia remains a diagnosis per exclusionem. There are no specific clinical symptoms or laboratory parameters to ensure diagnosis. In otherwise caused thrombocytopenias many authors found increased platelet-associated immunoglobin (PaIg) and platelet-binding serum immunoglobulin (PbSIg). Methods to determine PaIg and PbSIg are described and their clinical relevance is discussed. Determinations of PaIg and PbSIg with Ig-L-chain-specific ELISA are recommended. They improve diagnostic possibilities to distinguish ITP from nonimmune thrombocytopenias.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2203233