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[Immunodiagnosis of immune thrombocytopenias and their clinical significance].

Authors
  • Wietschel, F
  • Malberg, K
Type
Published Article
Journal
Allergie und Immunologie
Publication Date
Jan 01, 1990
Volume
36
Issue
2
Pages
67–76
Identifiers
PMID: 2203233
Source
Medline
License
Unknown

Abstract

Immune thrombocytopenia remains a diagnosis per exclusionem. There are no specific clinical symptoms or laboratory parameters to ensure diagnosis. In otherwise caused thrombocytopenias many authors found increased platelet-associated immunoglobin (PaIg) and platelet-binding serum immunoglobulin (PbSIg). Methods to determine PaIg and PbSIg are described and their clinical relevance is discussed. Determinations of PaIg and PbSIg with Ig-L-chain-specific ELISA are recommended. They improve diagnostic possibilities to distinguish ITP from nonimmune thrombocytopenias.

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