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Immunocytochemical studies for the localisation of measles antigens in multiple sclerosis plaques and measles virus-infected CNS tissue.

Authors
  • Raine, C S
  • Prineas, J W
  • Sheppard, R D
  • Bornstein, M B
  • Dubois-Dalcq, M
Type
Published Article
Journal
Journal of the Neurological Sciences
Publisher
Elsevier
Publication Date
Aug 01, 1977
Volume
33
Issue
1-2
Pages
13–30
Identifiers
PMID: 333059
Source
Medline
License
Unknown

Abstract

Actively demyelinating central nervous system (CNS) lesions from a patient with acute multiple sclerosis (MS) were tested for measles antigens using peroxidase-conjugated antimeasles antibody. No evidence of measles antigens was found. Similarly reacted tissue from 2 patients with chronic MS also revealed no evidence of measles antigens. Identically treated and simultaneously tested measles-infected CNS cultures and human SSPE brain tissue stained strongly for measles antigens. The possible reasons underlying the failure to detect measles antigens in MS are discussed.

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