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Immunobiologic effects of cytokine gene transfer of the B16-BL6 melanoma.

Authors
  • Strome, S E1
  • Krauss, J C
  • Cameron, M J
  • Forslund, K
  • Shu, S
  • Chang, A E
  • 1 Department of Otolaryngology, Division of Hematology and Oncology, University of Michigan, Ann Arbor, USA.
Type
Published Article
Journal
Archives of otolaryngology--head & neck surgery
Publication Date
Dec 01, 1993
Volume
119
Issue
12
Pages
1289–1295
Identifiers
PMID: 17431982
Source
Medline
License
Unknown

Abstract

We observed diverse immunobiologic effects associated with cytokine gene transfer into the B16-BL6 melanoma. Interleukin 4 transfection of tumor resulted in decreased in vivo tumorigenicity that may be related to a host immune response. Further studies to evaluate the host T-cell response to these gene-modified tumors are being investigated.

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