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The immuno-stimulant OK-432 enhances liver regeneration after 70% hepatectomy.

Authors
  • Kato, K
  • Onodera, K
  • Kato, J
  • Kasai, S
  • Mito, M
Type
Published Article
Journal
Journal of Hepatology
Publisher
Elsevier
Publication Date
Jul 01, 1995
Volume
23
Issue
1
Pages
87–94
Identifiers
PMID: 8530815
Source
Medline
License
Unknown

Abstract

The effect of reticuloendothelial system activation on hepatic regeneration after 70% hepatectomy was investigated. OK-432, a killed streptococcal preparation which increases reticuloendothelial system function, was administered to rats prior to 70% hepatectomy. Hepatic incorporation of 3H-thymidine 24 h after 70% hepatectomy was enhanced by OK-432 pretreatment. DNA synthesis was greater in pretreated than in control rats and correlated highly with reticuloendothelial system phagocytic activity prior to surgery. Methyl palmitate, which decreases reticuloendothelial system function, was administered to rats prior to 70% hepatectemy. Hepatic incorporation of 3H-thymidine 24 h after 70% hepatoctomy was significantly depressed by methylpalmitate-pretreatment. These data suggest that reticuloendothelial system plays a role in liver regeneration and that hepatocyte proliferation might be enhanced by protection from surgical stress and endotoxins with reticuloendothelial system stimulation by OK-432.

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