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Immunization with Recombinant Streptococcus pneumoniae Neuraminidase NanA Protects Chinchillas against Nasopharyngeal Colonization

Authors
  • H. H. Tong
  • D. Li
  • S. Chen
  • J. P. Long
  • T. F. DeMaria
Publisher
American Society for Microbiology
Publication Date
Nov 01, 2005
Source
PMC
Keywords
License
Unknown

Abstract

Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.

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