Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Immunization strategies against henipaviruses.

Authors
Type
Published Article
Journal
Current topics in microbiology and immunology
0070-217X
Publication Date
Volume
359
Pages
197–223
Identifiers
DOI: 10.1007/82_2012_213
PMID: 22481140
Source
Medline
License
Unknown

Abstract

Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

Statistics

Seen <100 times