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Immunization with HBsAg-Fc fusion protein induces a predominant production of Th1 cytokines and reduces HBsAg level in transgenic mice.

Authors
  • Meng, Zhe-feng
  • Wang, Hua-jing
  • Yao, Xin
  • Wang, Xuan-yi
  • Wen, Yu-mei
  • Dai, Jian-xin
  • Xie, You-hua
  • Xu, Jian-qing
Type
Published Article
Journal
Chinese medical journal
Publication Date
Sep 01, 2012
Volume
125
Issue
18
Pages
3266–3272
Identifiers
PMID: 22964321
Source
Medline
License
Unknown

Abstract

HBsAg-Fc is effective in eliciting both the humoral and cellular immune responses against HBsAg in HBsAg transgenic mice, which makes it a potential immunogen for the immunotherapy of chronic hepatitis B.

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