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Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice.

Authors
  • Lu, Xinjie
  • Xia, Min
  • Endresz, Valeria
  • Faludi, Ildiko
  • Mundkur, Lakshmi
  • Gonczol, Eva
  • Chen, Daxin
  • Kakkar, Vijay V
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Oct 01, 2012
Volume
32
Issue
10
Pages
2358–2371
Identifiers
DOI: 10.1161/ATVBAHA.112.253179
PMID: 22837469
Source
Medline
License
Unknown

Abstract

Immunization of mice with C5aR-P1 and C5aR-P2, either alone or in combination, was effective in reducing early atherosclerotic lesion development. The combined peptide is more potential than either epitope alone to reduce atherosclerotic lesion formation through the induction of a specific Treg cell response as well as blockage of monocyte differentiation into macrophages.

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