Affordable Access

Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters.

Authors
  • Wakelin, D
  • Lloyd, M
Type
Published Article
Journal
Parasitology
Publication Date
Apr 01, 1976
Volume
72
Issue
2
Pages
173–182
Identifiers
PMID: 1264489
Source
Medline
License
Unknown

Abstract

In young (6- to 8-week-old) NIH strain inbred mice expulsion of a primary infection of Trichinella spiralis began on day 8 and was virtually complete by day 11-5. In older mice expulsion occurred 1 or 2 days earlier. Experience of a primary infection elicited strong immunity to challenge, whether the challenge was given immediately after worm expulsion (day 14) or delayed (day 42). Challenge infections were expelled rapidly the majority of worms being lost during the first day. Immunity to challenge was elicited by low-level primary infections and was effective against large ventionally accepted parameters of immunity to T. spiralis in mice which, it is considered, are applicable only to mice with a genetically determined low-level of responsiveness to the parasite.

Report this publication

Statistics

Seen <100 times