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Immune-suppressive properties of the tumor microenvironment

Authors
  • Becker, Jürgen C.1
  • Andersen, Mads Hald2
  • Schrama, David1
  • thor Straten, Per2
  • 1 Medical University of Graz, Department of General Dermatology, Auenbruggerplatz 8, Graz, 8010, Austria , Graz (Austria)
  • 2 University Hospital Herlev, Department of Hematology, Center for Cancer Immune Therapy (CCIT), Herlev Ringvej 75, Herlev, 2730, Denmark , Herlev (Denmark)
Type
Published Article
Journal
Cancer Immunology Immunotherapy
Publisher
Springer-Verlag
Publication Date
May 11, 2013
Volume
62
Issue
7
Pages
1137–1148
Identifiers
DOI: 10.1007/s00262-013-1434-6
Source
Springer Nature
Keywords
License
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Abstract

Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. Here, we will focus on immune-modulating capacities of the tumor microenvironment.

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