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Immune responses induced by co-infection with Capillaria hepatica in Clonorchis sinensis-infected rats.

Authors
  • Moon, E-K1
  • Lee, S-H2
  • Goo, T W3
  • Quan, F-S1
  • 1 Department of Medical Zoology,Kyung Hee University School of Medicine,Seoul,Korea. , (North Korea)
  • 2 Department of Biomedical Science,Graduate School,Kyung Hee University,Seoul,Korea. , (North Korea)
  • 3 Department of Biochemistry,College of Medicine, Dongguk University,Gyeongju,Republic of Korea. , (North Korea)
Type
Published Article
Journal
Journal of helminthology
Publication Date
Aug 08, 2017
Pages
1–8
Identifiers
DOI: 10.1017/S0022149X17000682
PMID: 28784187
Source
Medline
License
Unknown

Abstract

Clonorchis sinensis and Capillaria hepatica are zoonotic parasites that mainly infect the liver and cause serious liver disorders. However, immunological parameters induced by co-infection with these parasites remain unknown. In this study, for the first time, we investigated immunological profiles induced by co-infection with C. hepatica (CH) in C. sinensis (CS)-infected rats (Sprague-Dawley). Rats were infected primarily with 50 metacercariae of C. sinensis; 4 weeks later, they were subsequently infected with 1000 infective C. hepatica eggs. Significantly higher levels of C. sinensis- or C. hepatica-specific IgG antibodies were found in the sera of rats. Interestingly, no cross-reacting antibody was observed between C. sinensis and C. hepatica infections. Significantly raised eosinophil levels were found in the blood of C. sinensis/C. hepatica co-infected rats (CS + CH) compared to the blood of rats infected singly with C. sinensis. Co-infected rats showed significantly higher levels of lymphocyte proliferation and cytokine production compared to a single C. sinensis infection. The worm burden of C. sinensis was significantly reduced in co-infected rats compared to the single C. sinensis infection. These results indicate that the eosinophils, lymphocyte proliferation and cytokine production induced by subsequent infection with C. hepatica in C. sinensis-infected rats might contribute to the observed C. sinensis worm reduction.

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