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Immune responses in baboons vaccinated with HIV-2 genetic expression libraries.

Authors
  • Locher, C P
  • Sykes, K F
  • Blackbourn, D J
  • Johnston, S A
Type
Published Article
Journal
Journal of medical primatology
Publication Date
Dec 01, 2002
Volume
31
Issue
6
Pages
323–329
Identifiers
PMID: 12519210
Source
Medline
License
Unknown

Abstract

Immunization using genetic expression libraries may be an improvement over conventional DNA immunization using a single gene because more epitopes are simultaneously presented to the immune system. In this study, we evaluated the effectiveness of an HIV-2 vaccine made from a genomic expression library in baboons. We found that HIV-2 expression library immunization induced HIV-2-specific memory responses but low levels of CD8+ cell anti-viral responses and neutralizing antibodies. After intravenous virus challenge using a homologous pathogenic variant, HIV-2UC2/9429, viral loads were similar in the HIV-2-immunized and control baboons. We conclude that although immunization using HIV-2 expression libraries induces immune responses, this approach does not provide protection in baboons against intravenous challenge with HIV-2.

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