This article presents an interview with Dr. Sharilyn K. Stanley regarding her study on how immune system activation boosts HIV replication in HIV-infected people. Asked to give a brief outline of the study, Stanley noted that a single booster dose of tetanus toxoid was given to HIV-infected and uninfected volunteers in order to stimulate their immune system. In the evaluation that followed, high levels of HIV circulating in the blood of HIV-infected patients and uninfected individuals were found. In terms of insights gained into the cellular environment and how the immune system works, Stanley specified that previous work has shown the regulation of HIV expression by cytokines, the molecules that the immune system uses to signal itself. Moreover, Stanley comments that by rapidly and effectively diagnosing and treating infections associated with HIV, a huge increase in virus may be avoided when the immune systems of HIV-infected people are activated. Furthermore, future studies complementing the findings of the study and proposed studies in developing countries were revealed by Stanley.