Affordable Access

deepdyve-link
Publisher Website

Immune reconstitution inflammatory syndrome in HIV-infected patients.

Authors
  • Walker, Naomi F
  • Scriven, James
  • Meintjes, Graeme
  • Wilkinson, Robert J
Type
Published Article
Journal
HIV/AIDS (Auckland, N.Z.)
Publication Date
Jan 01, 2015
Volume
7
Pages
49–64
Identifiers
DOI: 10.2147/HIV.S42328
PMID: 25709503
Source
Medline
Keywords
License
Unknown

Abstract

Access to antiretroviral therapy (ART) is improving worldwide. Immune reconstitution inflammatory syndrome (IRIS) is a common complication of ART initiation. In this review, we provide an overview of clinical and epidemiological features of HIV-associated IRIS, current understanding of pathophysiological mechanisms, available therapy, and preventive strategies. The spectrum of HIV-associated IRIS is described, with a particular focus on three important pathogen-associated forms: tuberculosis-associated IRIS, cryptococcal IRIS, and Kaposi's sarcoma IRIS. While the clinical features and epidemiology are well described, there are major gaps in our understanding of pathophysiology and as a result therapeutic and preventative strategies are suboptimal. Timing of ART initiation is critical to reduce IRIS-associated morbidity. Improved understanding of the pathophysiology of IRIS will hopefully enable improved diagnostic modalities and better targeted treatments to be developed.

Report this publication

Statistics

Seen <100 times