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Immune reactivity against membranes containing ganglioside GM1 in chronic-progressive multiple sclerosis: observation by spin-membrane immunoassay.

Authors
  • Feix, J B
  • Khatri, B
  • McQuillen, M P
  • Koethe, S M
Type
Published Article
Journal
Immunological Communications
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jan 01, 1984
Volume
13
Issue
5
Pages
465–474
Identifiers
PMID: 6097532
Source
Medline
License
Unknown

Abstract

A spin-membrane immunoassay has been employed to examine the immune reactivity of whole serum from patients with chronic-progressive multiple sclerosis (CPMS) against liposomes containing ganglioside GM1. Exposure to serum resulted in complement-mediated lysis of the GM1-liposomes. No lysis occurred with liposomes devoid of ganglioside. The mean (+/- S.E.M.) lysis values were 52.6 (+/- 9.8)% for fifteen CPMS patients and 32.9 (+/- 7.2)% for nine controls. The difference between the means was highly significant (student's t-test, P less than 0.0001), indicating increased anti-ganglioside immunity in patients with CPMS.

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