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[Immune mechanisms in pathogenesis of chronic heart failure].

Authors
  • Egorova, E N
  • Kalinkin, M N
  • Mazur, E S
Type
Published Article
Journal
Patologicheskaia fiziologiia i èksperimental'naia terapiia
Publication Date
Jan 01, 2012
Issue
2
Pages
56–61
Identifiers
PMID: 22708411
Source
Medline
License
Unknown

Abstract

In the review the new information about a participation of immune mechanisms in a pathogenesis of a chronic heart failure (CHF) is presented. Significance of a bacterial endotoxin, as inductor of activation of immune system at CHF, and factors of a system inflammation in a pathogenesis of the disease, breaking balance of matrix metalloproteinases and tissue inhibitors of metalloproteinases system, leading to change of structure of an extracellular matrix of a myocardium, are discussed.

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