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Immune deficiency and autoimmunity.

Authors
  • Atkinson, Thomas Prescott
Type
Published Article
Journal
Current Opinion in Rheumatology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Sep 01, 2012
Volume
24
Issue
5
Pages
515–521
Identifiers
DOI: 10.1097/BOR.0b013e32835680c6
PMID: 22820513
Source
Medline
License
Unknown

Abstract

Autoimmunity has long been known to be a part of the presenting symptoms and clinical course of many primary immunodeficiencies. This review will provide an overview of the new concepts regarding the complex relationship between the genetic immune deficiencies and autoimmunity. The mechanisms by which immunodeficiency may lead to autoimmunity or, in some instances, by which autoimmunity produces immunodeficiency can provide important insights into the underlying pathogenic processes and ultimately better diagnosis and treatment for the patient.

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