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[Immune cells in atherosclerosis--good or bad?].

Authors
  • Klingenberg, Roland1
  • Matter, Christian M1
  • Lüscher, Thomas F1
  • 1 1 Universitäres Herzzentrum, Klinik für Kardiologie, Universitätsspital Zürich.
Type
Published Article
Journal
Praxis
Publication Date
Apr 13, 2016
Volume
105
Issue
8
Pages
437–444
Identifiers
DOI: 10.1024/1661-8157/a002319
PMID: 27078727
Source
Medline
Keywords
License
Unknown

Abstract

Inflammation is a major mediator of atherosclerosis and plays a pivotal role for both innate and adaptive immunity in the onset and the progression of atherosclerosis. Novel insights into how the adaptive immune system is activated and propagates atherosclerosis elucidate the intricate interplay of different subsets of lymphocytes and their mediators as a central feature of vascular inflammation. The recognition of an inherent anti-inflammatory component of the adaptive immune system mediated by regulatory T (Treg) cells outline a novel concept: the expansion of regulatory T cells to reduce atherosclerosis. Based on a variety of research results, this concept represents a new therapeutic option in patients with atherosclerosis.

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