Affordable Access

Access to the full text

Immune cell migration in inflammation: present and future therapeutic targets

Authors
  • Luster, Andrew D1
  • Alon, Ronen2
  • von Andrian, Ulrich H3
  • 1 Center for Immunology and Inflammatory Diseases, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114, USA , Boston (United States)
  • 2 Weizmann Institute of Science, Rehovot, 76100, Israel , (Israel)
  • 3 Harvard Medical School, Boston, Massachusetts, 02115, USA , Boston (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Nov 17, 2005
Volume
6
Issue
12
Pages
1182–1190
Identifiers
DOI: 10.1038/ni1275
Source
Springer Nature
License
Yellow

Abstract

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in the clinic. Trafficking signals are being defined that finely control the movement of distinct subsets of immune cells into and out of specific tissues. Because the accumulation of leukocytes in tissues contributes to a wide variety of diseases, these 'molecular codes' have provided new targets for inhibiting tissue-specific inflammation, which have been confirmed in the clinic. However, immune cell migration is also critically important for the delivery of protective immune responses to tissues. Thus, the challenge for the future will be to identify the trafficking molecules that will most specifically inhibit the key subsets of cells that drive disease processes without affecting the migration and function of leukocytes required for protective immunity.

Report this publication

Statistics

Seen <100 times