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[Immortal time bias in pharmacoepidemiological studies: definition, solutions and examples].

Authors
  • Faillie, Jean-Luc
  • Suissa, Samy
Type
Published Article
Journal
Thérapie
Publication Date
Jan 01, 2015
Volume
70
Issue
3
Pages
259–263
Identifiers
DOI: 10.2515/therapie/2014207
PMID: 25487848
Source
Medline
License
Unknown

Abstract

Among the observational studies of drug effects in chronic diseases, many of them have found effects that were exaggerated or wrong. Among bias responsible for these errors, the immortal time bias, concerning the definition of exposure and exposure periods, is relevantly important as it usually tends to wrongly attribute a significant benefit to the study drug (or exaggerate a real benefit). In this article, we define the mechanism of immortal time bias, we present possible solutions and illustrate its consequences through examples of pharmacoepidemiological studies of drug effects.

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