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Imiquimod reactivation of lichen planus.

Authors
  • Domingues, Erik
  • Chaney, Keri C
  • Scharf, Mark J
  • Wiss, Karen
Type
Published Article
Journal
Cutis
Publication Date
Jun 01, 2012
Volume
89
Issue
6
Identifiers
PMID: 22838091
Source
Medline
License
Unknown

Abstract

A 44-year-old man who was previously diagnosed with actinic cheilitis was prescribed imiquimod cream 5%, which resulted in thick hemorrhagic crusting of the lower lip after 4 applications. He subsequently noted the development of lichen planus lesions on his arms and legs for the first time in 15 years following imiquimod use. On follow-up he also was noted to have characteristic Wickham striae on his lower lip. Lichen planus is an autoimmune inflammatory condition in which autoreactive T lymphocytes attack keratinocytes. The mechanism of action for imiquimod is upregulation of IFN-alpha and IFN-beta. Treatment with clobetasol cream 0.05% led to resolution of his lichen planus lesions.

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