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Imipramine does not act as a false transmitter in the rat hypothalamus.

Authors
Type
Published Article
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
267
Issue
1
Pages
161–164
Identifiers
PMID: 6134569
Source
Medline
License
Unknown

Abstract

[3H]Imipramine was accumulated by rat hypothalamic slices mostly by a passive low-affinity process. Accumulated [3H]imipramine was released by 60 mM potassium, but the release was small and was not Ca2+-dependent. Imipramine induced some release of [3H]norepinephrine. None of these events were abolished by pretreatment of the rats with reserpine. These results do not favor the view that imipramine acts as a false transmitter in the rat hypothalamus. Rather, imipramine appears to be accumulated in an extragranular pool from which it releases extragranular norepinephrine.

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