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[Imbalanced T cell-specific transcription factors T-bet and GATA-3 contributes to type 2 T helper cell polarization in asthmatic patients].

Authors
  • Liu, Chun-Tao
  • Wang, Gang
  • Luo, Feng-Ming
  • Wang, Zeng-Li
  • Liu, Rui
  • Wang, Ci-Lin
Type
Published Article
Journal
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Publication Date
Jun 01, 2004
Volume
27
Issue
6
Pages
398–402
Identifiers
PMID: 15256090
Source
Medline
License
Unknown

Abstract

In asthma there is a tendency of Th2 polarization with over-production of Th2-like cytokines in which T-bet deficiency may be a key factor. T-bet might direct T cells to Th1 differentiation while GATA-3 orientated Th2 maturation. Considering the fact that committed Th2 cells underwent re-differentiation induced by T-bet, this novel Th1-specific transcription factor is a fascinating target gene for modifying to restore the Th1 and Th2 balance.

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