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Imbalance of circulating endothelial cells and progenitors in idiopathic pulmonary fibrosis.

Authors
  • Smadja, David M1
  • Mauge, Laetitia
  • Nunes, Hilario
  • d'Audigier, Clément
  • Juvin, Karine
  • Borie, Raphael
  • Carton, Zohra
  • Bertil, Sébastien
  • Blanchard, Anne
  • Crestani, Bruno
  • Valeyre, Dominique
  • Gaussem, Pascale
  • Israel-Biet, Dominique
  • 1 Hematology Department, European Georges Pompidou Hospital, Université Paris Descartes, France. [email protected] , (France)
Type
Published Article
Journal
Angiogenesis
Publisher
Springer-Verlag
Publication Date
Jan 01, 2013
Volume
16
Issue
1
Pages
147–157
Identifiers
DOI: 10.1007/s10456-012-9306-9
PMID: 22983452
Source
Medline
License
Unknown

Abstract

IPF is basically associated with both a vascular injury and a repair defect. This study highlights an adaptative process of EPC mobilization in the most severe forms of IPF, that could reflect enhanced homing to the pulmonary vasculature, which clinical consequences remain to be determined.

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