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Imatinib-loaded polyelectrolyte microcapsules for sustained targeting of BCR-ABL+ leukemia stem cells.

Authors
Type
Published Article
Journal
Nanomedicine
1748-6963
Publisher
Future Medicine
Publication Date
Volume
5
Issue
3
Pages
419–431
Identifiers
DOI: 10.2217/nnm.10.8
PMID: 20394535
Source
Medline
License
Unknown

Abstract

This pilot study provides the proof-of-principle for the clinical application of biodegradable IM-loaded PMC as feasible, safe and effective ex vivo purging agents to target CML stem cells, in order to improve transplant outcome of resistant/relapsed patients or reduce IM dose escalation.

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