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Imatinib-loaded polyelectrolyte microcapsules for sustained targeting of BCR-ABL+ leukemia stem cells.

Authors
  • Palamà, Ilaria E
  • Leporatti, Stefano
  • de Luca, Emanuela
  • Di Renzo, Nicola
  • Maffia, Michele
  • Gambacorti-Passerini, Carlo
  • Rinaldi, Ross
  • Gigli, Giuseppe
  • Cingolani, Roberto
  • Coluccia, Addolorata M L
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
Apr 01, 2010
Volume
5
Issue
3
Pages
419–431
Identifiers
DOI: 10.2217/nnm.10.8
PMID: 20394535
Source
Medline
License
Unknown

Abstract

This pilot study provides the proof-of-principle for the clinical application of biodegradable IM-loaded PMC as feasible, safe and effective ex vivo purging agents to target CML stem cells, in order to improve transplant outcome of resistant/relapsed patients or reduce IM dose escalation.

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