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Imaging integrin αvβ 3 and NRP-1 positive gliomas with a novel fluorine-18 labeled RGD-ATWLPPR heterodimeric peptide probe.

Authors
  • Wu, Hua
  • Chen, Haojun
  • Pan, Dongfeng
  • Ma, Yufei
  • Liang, Sheng
  • Wan, Ying
  • Fang, Ya
Type
Published Article
Journal
Molecular Imaging and Biology
Publisher
Springer-Verlag
Publication Date
Dec 01, 2014
Volume
16
Issue
6
Pages
781–792
Identifiers
DOI: 10.1007/s11307-014-0761-0
PMID: 25001194
Source
Medline
License
Unknown

Abstract

[(18)F]FAl-NOTA-RGD-ATWLPPR exhibited significantly improved receptor-targeting properties both in vitro and in vivo compared with the F-18 labeled RGD or ATWLPPR monomers. The improved targeting and localization exhibited by the RGD-ATWLPPR heterodimer provide a foundation for further investigations of its applicability in clinical tumor imaging.

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