Affordable Access

Access to the full text

Imaging, Identification and Inhibition of Microorganisms Using AIEgens

Authors
  • Perera, Harini A.1
  • Yan, Mingdi1
  • 1 University of Massachusetts Lowell, Lowell, MA, 01854, USA , Lowell (United States)
Type
Published Article
Journal
Topics in Current Chemistry
Publisher
Springer International Publishing
Publication Date
Apr 09, 2021
Volume
379
Issue
3
Identifiers
DOI: 10.1007/s41061-021-00333-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

Microorganisms, including bacteria, viruses and fungi, are ubiquitous in nature. Some are extremely beneficial to life on Earth, whereas some cause diseases and disrupt normal human physiology. Pathogenic microorganisms can also undergo mutations and develop resistance to antimicrobial agents, which complicates diagnostic and therapeutic regimens. This calls for continuing efforts to develop new strategies and tools that can provide fast, sensitive and accurate diagnosis, as well as effective treatment of ever-evolving infectious diseases. Aggregation-induced emission luminogens (AIEgens) have shown promise in imaging, identification and inhibition of various microbial species. Compared to conventional organic fluorophores, AIEgens can offer improved photostability, and have found utilities in imaging microorganisms. AIEgens have been shown to detect microbial viability and differentiate among different microbial strains. Theranostic AIEgens that integrate imaging and killing of microbes have also been developed. This review highlights examples in the literature where AIEgens have been employed as molecular probes in the imaging, discrimination and killing of bacteria, viruses and fungi.

Report this publication

Statistics

Seen <100 times