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Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer.

Authors
  • Cornelissen, Bart
  • Able, Sarah
  • Kartsonaki, Christiana
  • Kersemans, Veerle
  • Allen, P Danny
  • Cavallo, Federica
  • Cazier, Jean-Baptiste
  • Iezzi, Manuela
  • Knight, James
  • Muschel, Ruth
  • Smart, Sean
  • Vallis, Katherine A
Type
Published Article
Publication Date
Dec 01, 2014
Volume
55
Issue
12
Pages
2026–2031
Identifiers
DOI: 10.2967/jnumed.114.142083
PMID: 25453049
Source
Medline
Keywords
License
Unknown

Abstract

DDR imaging using (111)In-anti-γH2AX-TAT identified mammary tumors significantly earlier than MR imaging. Imaging the DDR holds promise for the detection of preneoplasia and as a technique for screening cancer-prone individuals.

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