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Imaging of brain tumors with L-3-[123I]iodo-alpha-methyl tyrosine and SPECT.

Authors
  • Biersack, H J
  • Coenen, H H
  • Stöcklin, G
  • Reichmann, K
  • Bockisch, A
  • Oehr, P
  • Kashab, M
  • Rollmann, O
Type
Published Article
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Publication Date
Jan 01, 1989
Volume
30
Issue
1
Pages
110–112
Identifiers
PMID: 2783455
Source
Medline
License
Unknown

Abstract

Carbon-11-labeled amino acids have been successfully used to image brain tumors by PET. This study was undertaken to evaluate the potential of L-3-[123I]-iodo-alpha-methyl tyrosine (123IMT) for metabolic imaging of brain tumors. Ten patients (glioblastoma, oligodendroglioma, lymphoma, and metastases) had early and delayed brain SPECT with a rotating gamma camera after i.v.-injection of 200-300 MBq 123IMT. In nine patients the tumors showed intense uptake of the radiotracer. Tumor-to-brain tissue ratios were between 1.4 and 2.6. 123IMT shows potentials for monitoring the effects of brain tumor therapy.

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