Affordable Access

deepdyve-link
Publisher Website

Image acquisition for intravoxel incoherent motion imaging of kidneys should be triggered at the instant of maximum blood velocity: evidence obtained with simulations and in vivo experiments.

Authors
  • Milani, Bastien1, 2, 3
  • Ledoux, Jean-Baptiste2, 3
  • Rotzinger, David C2
  • Kanemitsu, Michiko1
  • Vallée, Jean-Paul4
  • Burnier, Michel1
  • Pruijm, Menno1
  • 1 Département de Medecine, Service de Néphrologie, Centre Hospitalier Universitaire Vaudois, Vaud, Switzerland. , (Switzerland)
  • 2 Département de Radiologie, Centre Hospitalier Universitaire Vaudois, Vaud, Switzerland. , (Switzerland)
  • 3 Center for Biomedical Imaging, Centre Hospitalier Universitaire Vaudois, Vaud, Switzerland. , (Switzerland)
  • 4 Département d'Imagerie et des Sciences de l'information Médicale, Hôpitaux Universitaires de Genève, Genève, Switzerland. , (Switzerland)
Type
Published Article
Journal
Magnetic Resonance in Medicine
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2019
Volume
81
Issue
1
Pages
583–593
Identifiers
DOI: 10.1002/mrm.27393
PMID: 30146728
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To demonstrate that diffusion-weighted images should be acquired at the instant of maximum blood velocity in kidneys to extract the perfusion fraction (PF) by the bi-exponential intravoxel incoherent motion model. The PF values were measured in Monte-Carlo simulations corresponding to different blood velocities with a constant known PF. The distribution of the measured PF values (PF-distribution) was characterized quantitatively by 3 markers highlighting the deviation of the measurement from the true PF. Diffusion-weighted images of kidneys were acquired in 10 healthy volunteers at the instant of maximal respectively minimal blood velocity in the renal artery (Vmax versus Vmin acquisition). The PF-distributions measured from the Vmax and Vmin acquisitions were compared mutually and with simulated PF-distributions using the 3 markers. A radiologist evaluated the quality of the PF maps. The PF-distributions measured in the simulations were spread around the true PF value, and spreading was reduced as blood velocity increased. A comparison between simulated and in vivo PF-distributions suggests that a similar phenomenon is plausible in vivo. The quality of the PF maps of the Vmax -acquisition was scored higher by the radiologist than those of the Vmin -acquisition in 95% of cases (19 of 20). The PF maps are of better quality when the Vmax -acquisition is used. We show evidence supporting the hypothesis that the variation of PF along the cardiac cycle is due to oscillations between a poor estimation when the blood velocity is low, and a better estimation when blood velocity is higher. © 2018 International Society for Magnetic Resonance in Medicine.

Report this publication

Statistics

Seen <100 times