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Iliac crest biopsy in longitudinal therapeutic trials of osteoporosis.

Authors
Type
Published Article
Journal
Bone and Mineral
0169-6009
Publisher
Elsevier
Publication Date
Volume
5
Issue
1
Pages
77–87
Identifiers
PMID: 3214682
Source
Medline
License
Unknown

Abstract

Changes in tetracycline-labelled iliac crest biopsies taken before and after 1 year of treatment with nandrolone decanoate + calcium, 17 beta-estradiol + norethisterone acetate + calcium or placebo were compared with changes in plasma bone Gla protein (pBGP), serum alkaline phosphatase (sAP), whole body retention (WBR) of Technetium-99m-diphosphonate [( 99mTc]DP) and bone mineral content (BMC) of the forearm. Based on a comparison between biopsy and noninvasive results, as well as on evaluation of the variation in the groups, certain guidelines for the use of bone histomorphometry in longitudinal therapeutic trials are suggested. It is proposed that bone biopsy is not used to monitor changes in amount of bone and that evaluation of changes in biopsy evaluated bone turnover is only attempted when the groups are large.

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