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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

Authors
  • Schuijs, Martijn J.1
  • Png, Shaun1
  • Richard, Arianne C.1, 1
  • Tsyben, Anastasia1, 2
  • Hamm, Gregory3
  • Stockis, Julie1
  • Garcia, Celine1
  • Pinaud, Silvain1
  • Nicholls, Ashley1
  • Ros, Xavier Romero3
  • Su, Jing1
  • Eldridge, Matthew D.1
  • Riedel, Angela1
  • Serrao, Eva M.1
  • Rodewald, Hans-Reimer4
  • Mack, Matthias5
  • Shields, Jacqueline D.1
  • Cohen, E. Suzanne3
  • McKenzie, Andrew N. J.6
  • Goodwin, Richard J. A.3, 7
  • And 3 more
  • 1 University of Cambridge, Cambridge, UK , Cambridge (United Kingdom)
  • 2 Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK , Cambridge (United Kingdom)
  • 3 BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK , Cambridge (United Kingdom)
  • 4 German Cancer Research Center, Heidelberg, Germany , Heidelberg (Germany)
  • 5 University Hospital Regensburg, Regensburg, Germany , Regensburg (Germany)
  • 6 MRC Laboratory of Molecular Biology, Cambridge, UK , Cambridge (United Kingdom)
  • 7 University of Glasgow, Glasgow, UK , Glasgow (United Kingdom)
  • 8 Wellcome Genome Campus, Cambridge, UK , Cambridge (United Kingdom)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 03, 2020
Volume
21
Issue
9
Pages
998–1009
Identifiers
DOI: 10.1038/s41590-020-0745-y
Source
Springer Nature
License
Yellow

Abstract

Pathological group 2 innate lymphoid cells (ILC2s) have mainly been implicated in allergy. Halim and colleagues demonstrate that ILC2s orchestrate a prometastatic pathway via the recruitment of eosinophils that suppress NK cell function.

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