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ILC1: guardians of the oral mucosa against enemy viruses

Authors
  • Nabekura, Tsukasa1, 2, 3
  • Shibuya, Akira1, 2, 3
  • 1 Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
  • 2 Department of Immunology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
  • 3 R&D Center for Innovative Drug Discovery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
Type
Published Article
Journal
Immunity
Publication Date
Feb 09, 2021
Volume
54
Issue
2
Pages
196–198
Identifiers
DOI: 10.1016/j.immuni.2021.01.002
PMID: 33567258
PMCID: PMC7871888
Source
PubMed Central
License
Unknown

Abstract

Type 1 innate lymphoid cells (ILC1s) regulate inflammation in the tissues; however, their role in anti-viral immunity remains largely unknown. In this issue of Immunity , Shannon et al. report that ILC1s invoke an anti-viral effect by producing interferon (IFN)-γ at homeostasis, thereby limiting viral replication in the oral mucosa.

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