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IL-8 Is Involved in Estrogen-Related Receptor α-Regulated Proliferation and Migration of Colorectal Cancer Cells.

Authors
  • Ding, Sijuan1
  • Tang, Zhaohui2
  • Jiang, Yongjun1
  • Huang, Honglin1
  • Luo, Pengfei1
  • Qing, Bohua1
  • Zhang, Siyuan1
  • Tang, Ruoting1
  • 1 Department of Oncology, The Central Hospital of Yongzhou, No. 396, Yiyun Road, Lengshuitan District, Yongzhou City, 425000, China. , (China)
  • 2 Department of Oncology, The Central Hospital of Yongzhou, No. 396, Yiyun Road, Lengshuitan District, Yongzhou City, 425000, China. [email protected] , (China)
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Dec 01, 2017
Volume
62
Issue
12
Pages
3438–3446
Identifiers
DOI: 10.1007/s10620-017-4779-4
PMID: 28993941
Source
Medline
Keywords
License
Unknown

Abstract

Our data showed that ERRα can trigger the proliferation and migration of CRC cells via up regulation of IL-8. Therefor targeted inhibition of ERRα/IL-8 might be a potential approach for CRC treatment and drug development.

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