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IL-22 Promotes Neural Stem Cell Self-Renewal in the Adult Brain

  • Coronas, Valérie
  • Arnault, Patricia
  • Jégou, Jean-François
  • Cousin, Laetitia
  • Rabeony, Hanitriniaina
  • Clarhaut, Sandrine
  • Harnois, Thomas
  • Lecron, Jean-Claude
  • Morel, Franck
Publication Date
Jan 01, 2023
DOI: 10.1093/stmcls/sxad003
PMID: 36635952
OAI: oai:HAL:hal-04003042v1
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Mainly known for its role in immune defense and inflammation, interleukin 22 (IL-22) has emerged over the past decade as a cytokine involved in the adaptation of stem/progenitor cell activity for tissue homeostasis and repair. IL-22 is present in the brain, which harbors neural stem cells (NSC) in specific niches of which the ventricular-subventricular zone (V-SVZ) is the most important. In this study, we examined a possible effect of IL-22 on NSC in the adult mouse brain. We demonstrate that the IL-22 receptor is expressed in the V-SVZ, mainly in NSC characterized by their SOX2 expression. Addition of IL-22 to V-VSZ cell cultures resulted in an increase in NSC self-renewal, associated with a shift in NSC division mode towards symmetric proliferative divisions at the expense of differentiative divisions. Conversely, loss of IL-22 in knockout mice led to a decrease in neurosphere yield, suggesting a reduction in the NSC population, which was confirmed by the decrease in cells retaining BrdU labeling in IL-22 knockout mice. Our study supports that IL-22 is involved in the development and/or maintenance of V-VSZ NSC and opens new avenues to further investigate the role of IL-22 in NSC biology in health and disease.

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