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IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase.

Authors
  • Balakrishnan, Lavanya
  • Soman, Sowmya
  • Patil, Yatish B
  • Advani, Jayshree
  • Thomas, Joji Kurian
  • Desai, Dattatraya Venkatesh
  • Kulkarni-Kale, Urmila
  • Harsha, H C
  • Prasad, T S Keshava
  • Raju, Rajesh
  • Pandey, Akhilesh
  • Dimitriadis, Eva
  • Chatterjee, Aditi
Type
Published Article
Journal
Cell communication & adhesion
Publication Date
Aug 01, 2013
Volume
20
Issue
3-4
Pages
81–86
Identifiers
DOI: 10.3109/15419061.2013.791683
PMID: 23631681
Source
Medline
License
Unknown

Abstract

Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.

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