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IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: preliminary findings.

Authors
  • Gelati, M
  • Lamperti, E
  • Dufour, A
  • Corsini, E
  • Venegoni, E
  • Milanese, C
  • Nespolo, A
  • Salmaggi, A
Type
Published Article
Journal
Italian journal of neurological sciences
Publication Date
Aug 01, 1997
Volume
18
Issue
4
Pages
191–194
Identifiers
PMID: 9323512
Source
Medline
License
Unknown

Abstract

IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA-stimulated PBMNCs from MS patients produced large amounts of the cytokine.

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