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IgM multiple myeloma: a diagnostic challenge in a patient with coexisting chronic lymphocytic leukaemia.

Authors
  • Hewamana, Saman
  • Pepper, Chris
  • Couzens, Steve
  • Thomas, Alun
  • Knapper, Steven
Type
Published Article
Journal
International Journal of Hematology
Publisher
Springer-Verlag
Publication Date
Nov 01, 2008
Volume
88
Issue
4
Pages
424–427
Identifiers
DOI: 10.1007/s12185-008-0179-z
PMID: 18846322
Source
Medline
License
Unknown

Abstract

As IgM multiple myeloma is a rare poorly characterised disease entity; there is only limited published data on its clinical, microscopic and immunophenotypic features. We report a 72-year-old man misdiagnosed as Waldenström's macroglobulinemia. Also the diagnosis was further complicated by coexisting chronic lymphocytic leukaemia. Following confirmation of IgM myeloma, in view of the patient's deteriorating clinical condition; he was entered into the UK Medical Research Council Myeloma IX trial where he had partial response to chemotherapy. This case highlights the value of detailed immunophenotypic evaluation when clinical and morphological markers are equivocal.

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