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IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis

Authors
  • Witte, T.1
  • Hartung, K.2
  • Sachse, C.3
  • Matthias, T.4
  • Fricke, M.1
  • Deicher, H.1
  • Kalden, J. R.5
  • Lakomek, H. J.6
  • Peter, H. H.7
  • Schmidt, R. E.1
  • 1 Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany, Fax: 01149-511-5325648, e-mail: [email protected], DE
  • 2 Institut für Laboratoriums- und Transfusionsmedizin, Zentralkrankenhaus Reinkenheide, Bremerhaven, Germany, DE
  • 3 Abteilung Klinische Chemie II, Medizinische Hochschule Hannover, Hannover, Germany, DE
  • 4 ORGenTec Diagnostika GmbH, Mainz, Germany, DE
  • 5 Medizinische Klinik III der FAU Erlangen-Nürnberg, Erlangen, Germany, DE
  • 6 Klinik für Rheumatologie und Physikalische Medizin, Minden, Germany, DE
  • 7 Medizinische Universitätsklinik, Abteilung Rheumatologie und Klinische Immunologie, Freiburg Germany, DE
Type
Published Article
Journal
Rheumatology International
Publisher
Springer-Verlag
Publication Date
Oct 01, 1998
Volume
18
Issue
3
Pages
85–91
Identifiers
DOI: 10.1007/s002960050063
Source
Springer Nature
Keywords
License
Yellow

Abstract

Antibodies against dsDNA of the IgM class were measured in sera of 352 patients with systemic lupus erythematosus, 81 blood donors and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgM anti-dsDNA antibodies were found in 52.3% of the sera from patients with systemic lupus erythematosus, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 37 laboratory parameters was calculated. There was a highly significant negative correlation between IgM anti-dsDNA antibodies and nephritis as well as all the laboratory parameters indicating renal disease (elevated serum creatinine concentration, proteinuria, erythrocyte casts in the urine). IgM anti-dsDNA antibodies indicate protection of lupus patients against the development of lupus nephritis. Further experiments will show whether application of IgM anti-dsDNA antibodies is effective in treating lupus nephritis.

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