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IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens.

Authors
  • Santos, Alexandra F
  • James, Louisa K
  • Bahnson, Henry T
  • Shamji, Mohammed H
  • Couto-Francisco, Natália C
  • Islam, Sabita
  • Houghton, Sally
  • Clark, Andrew T
  • Stephens, Alick
  • Turcanu, Victor
  • Durham, Stephen R
  • Gould, Hannah J
  • Lack, Gideon
Type
Published Article
Journal
Journal of Allergy and Clinical Immunology
Publisher
Elsevier
Publication Date
May 01, 2015
Volume
135
Issue
5
Pages
1249–1256
Identifiers
DOI: 10.1016/j.jaci.2015.01.012
PMID: 25670011
Source
Medline
Keywords
License
Unknown

Abstract

Differences in sIgE levels and allergen specificity could not justify the clinical phenotype in all children with PA and PS children. Blocking IgG4 antibodies provide an additional explanation for the absence of clinical reactivity in PS patients sensitized to major peanut allergens.

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